Bloodstream viscosity and blood pressure: character from temperature and you will hyperglycemia

Yildirim Cinar, An excellent. Mete Senyol, Kamber Duman, Blood viscosity and you may blood circulation pressure: character away from heat and you may hyperglycemia, American Record from Blood circulation pressure, Frequency fourteen, Situation 5, , Pages 433–438,

Abstract

We planned a study to research the relations among blood pressure (BP), viscosity, and temperature in healthy subjects and among BP, viscosity, and glucose in diabetics. With simple random sampling method, 53 healthy and 29 diabetes mellitus (DM) type II subjects were selected. Parameters were determined with capillary viscometer and glucometer at 22°C, 36.5°C, and 39.5°C in healthy subjects, and at 22°C on diabetic patients during OGTT with 75 g of glucose. Statistical evaluations of the data were made with regression analysis, Student t test, Spearman’s correlation, and analysis of variance. When temperature decreased from 36.5°C to 22°C, blood viscosity increased %. This increase resulted in a % decrease in blood flow rate. According to the Hagen-Poiseuille equation, the required BP increase for compensation of the resulting tissue ischemia was %. Also, a % decrease in erythrocyte deformability and % increase in plasma viscosity were seen. When temperature increased from 36.5° to 39.5°C, blood viscosity decreased %. This caused % decrease in blood flow rate, and % decrease in BP, according to the equation. Erythrocyte deformability increase of 9.92% and plasma viscosity decrease of 4.99% arose from the temperature rise. There is a correlation between total data for temperatures and viscosities (r = ?0.84, P < .001). When the mean value of blood glucose increased from 100 to 400 mg/dL, viscosity increased 25% (r = 0.59, P = .002). In this state, blood flow rate decrease was 20% and BP increase for physiological compensation was 25%. Consequently, temperature, glucose and viscosity levels of blood are important factors for BP. Am J Hypertens 2001;–438 © 2001 American Journal of Hypertension, Ltd.

The aim of our very own research would be to check out the dating certainly heat, sugar concentration, and you can viscosity regarding bloodstream and you can plasma, and calculate their outcomes on blood pressure levels (BP) predicated on Hagen-Poiseuille’s hydrodynamics formula.

If the human circulatory system is considered as a closed system, hemodynamic equilibrium can be determined according to Poiseuille’s equation through the pressure, viscosity, flow rate, velocity of blood, and vessel diameter. Viscosity can be defined as the resistance of fluids against flow. The resistance for blood circulation includes friction between the blood elements and between the vessel lumen and blood. To make a fluid flow, the application of energy is required. Therefore, the energy of the circulatory system is spent in correlation with the viscosity level of blood. Energy forms of the circulatory system are BP and blood flow velocity. The velocity (v) and pressure of blood flow can be determined with Poiseuille’s equation as v = 1/4?L (F₁ ? F₂) (a 2 ? r 2 ), and also BP rate (Q) can be expressed from the above equation as Q = ?a 4 /8 ?L (F₁ ? F₂), where ? is the viscosity of the fluid, F₁ and F₂ are the initial and the final cross sectional pressures of blood, L is the length, a is the radius of vessel, and r is the distance from the center of the vessel for a flowing particle. 1, 2 Thus, to keep the equilibrium of the equation constant in the circulatory system, BP will increase when viscosity increases.

Blood viscosity and you can blood pressure levels: role of temperature and you can hyperglycemia

It’s been shown that anywhere between % and you can % opinions from hematocrit, all of the eleven% upsurge in hematocrit develops blood viscosity by 20%. Contained in this county, considering Poiseuille’s equation, circulation rate reduces by the %, that could end up in tissue ischemia. To keep the newest circulatory program into the harmony (that is, remaining this new flow price enough and you can blocking muscle ischemia), good 20% boost in BP or 4.66% vasodilation is necessary. 3 Yet not, the human circulatory system is perhaps not an exact closed system, once the blood viscosity would be changed toward absorption out-of dinner otherwise pills. 4–8 In addition, the effects of fat as well as certain drugs with the bloodstream viscosity and you will hemodynamics particularly BP anonymous gay hookup was advertised. Just like the atherosclerotic ships do not dilate well enough as a reaction to vasodilator drugs, it’s been recommended one to increased blood viscosity are only able to feel compensated with a beneficial BP rise in eg affairs. 9–twelve And additionally, new matchmaking certainly one of BP, horror, coagulation, circulation acceleration, and you can bloodstream viscosity were revealed through the principles out of hemodynamics. 13, fourteen